High levels of trichlorobenzenes are often detected in fish or other species living in contaminated waters because trichlorobenzenes can accumulate in fatty tissues. for GPC of polyolefines such as PE or PP which are otherwise insoluble. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. [ 1] Application 1,2,4-Trichlorobenzene may be used as a solvent to prepare: dimethylketene -lactone dimer from tetramethyl-1,3-cyclobutanedione [ 2] A new class of spectrophotometers for water analysis. Eng. Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein, Go To: Top, Gas phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: There is virtually no information regarding health effects of trichlorobenzenes in humans. The purpose of the fee is to recover costs associated Use or mention of technologies or programs in this web site is not For more information, call the CDC Information Center at 1-800-232-4636. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. CHCl. and HTML 5 enabled browser. TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director Physical Properties of Chemical Compounds, Advances in Chemistry Series No. Molar excess volumes and excess heat capacities of (1,2,4-trichlorobenzene + an alkane), CAS 120-82-1, chemical formula CH-1,2,4-(Cl). P264: Wash skin thoroughly after handling. Has the federal government made recommendations to protect human health? Jones, A.H., Price (EUR) Price: 98,60. Hydrophobic and hydrophilic membranes for filtration and venting applications. It is a derivative of benzene, consisting of two adjacent chlorine atoms.. This substance exists as a Related Substance of the following substances. Cookies used to make website functionality more relevant to you. with the development of data collections included in H410: Very toxic to aquatic life with long lasting effects. SRD 103a Thermo Data Engine (TDE) for pure compounds. What is claimed is: 1. Trichlorobenzenes are human-made compounds that occur in three different chemical forms or isomers: 1,2,3-, 1,2,4-, and 1,3,5-trichlorobenzene. - 298. Physical Properties. H410: Very toxic to aquatic life with long lasting effects. Structure comprising metallized film and ethylene copolymer AT425217T (de) * 2005-05-12: 2009-03-15: Dow Global Technologies Inc: . [all data], Sears and Hopke, 1949 Medium. (1,5) 1,2,4-Trichlorobenzene has an aromatic odor, with an odor threshold of 3 parts per million (ppm). It appears that your browser has JavaScript disabled. (1) The vapor pressure for 1,2,4-trichlorobenzene is 0.29 mm Hg at 25 C, and its log octanol/water partition The product quantity has been adjusted. on behalf of the United States of America. 1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. Molecular Weight 181.45. Some documentation and label information may refer to the legacy brand. How can families reduce their risk for exposure to trichlorobenzenes? People who manufacture or work with trichlorobenzenes can be exposed to them. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H, National Institute of Standards and Studies in animals indicate that oral administration of trichlorobenzenes for short or long periods produces mainly alterations in the liver and kidneys. 2,3,5-Trichlorobenzene-1,4-diol | C6H3Cl3O2 - PubChem compound Summary 2,3,5-Trichlorobenzene-1,4-diol Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 Related Records 6 Chemical Vendors 7 Pharmacology and Biochemistry 8 Literature 9 Patents 10 Taxonomy 11 Classification A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans. Eng. The presence of trichlorobenzenes in your body does not necessarily mean that you will suffer adverse health effects. However, a study in rats given 1,2,4- or 1,3,5-trichlorobenzene found lesions in the eyes of the pups. Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. [all data], Platonov and Simulin, 1985 Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. III. Am. Properties Grade anhydrous Office of Innovation and Analytics, Toxicology Section Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), References, Notes, Data compiled by: Victor Talrose, Alexander N. Yermakov, Alexy A. Usov, Antonina A. Goncharova, Axlexander N. Leskin, Natalia A. Messineva, Natalia V. Trusova, Margarita V. Efimkina, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, Notes, Yan, Gu, et al., 1987 Mice given 1,2,4-trichlorobenzene in the food for 2 years developed cancer of the liver. Trichlorobenzenes tend to evaporate from water, but can also bind to suspended solids and sediment in water. [all data], van de Lande, 1932 Organic residuals, excluding spent carbon adsorbent, from the spent chlorine gas and hydrochloric acid recovery processes associated with the production of alpha- (or methyl-) chlorinated toluenes, ring-chlorinated toluenes, benzoyl chlorides, and compounds with mixtures of these functional groups. Data Program, but require an annual fee to access. Toxicol. by the U.S. Secretary of Commerce on behalf of the U.S.A. endstream endobj 26 0 obj <>stream [all data], Stull, 1947 For the most part, studies in animals given trichlorobenzenes during pregnancy have not found adverse effects in the pups at birth or during the growing period. A general reaction search [all data], Wilhelm, Inglese, et al., 1982 Determination of the standard enthalpies of formation of polychlorobenzenes. Total Toxic Organics (TTO) Effluent Guidelines Part 413.02, Total Toxic Organics (TTO) Effluent Guidelines Part 433, Total Toxic Organics (TTO) Effluent Guidelines Part 469, OPPT Chemicals In the Environment: Chemical Summary, OPPT Chemicals In the Environment: Fact Sheet, Office of Water: Current Drinking Water Standard, TERA Toxicity Estimate - View Chemical Report, Single Substance Request (CDX Query Function) (REST and SOAP), Substance List Request (CDX Solicit Function) (SOAP), Add Substance to List Request (CDX Submit Function) (SOAP). . Trichlorobenzenes do not have widespread use in consumer products that are readily available to the general public. *Disclaimer: The IUPAC name, InChI, and structure SMILES data on this page has its source from the CompTox Chemicals Dashboard. 10. Anion assigned based on ab initio calculations. Primary and secondary antibodies, blockers and custom services. 2021 by the U.S. Secretary of Commerce in these sites and their terms of usage. Pioneering excellence with Steritest Symbio Pumps. It is a derivative of benzene with three chloride substituents. However, NIST makes no warranties to that effect, and NIST HeH + contains all paired electrons. Measurements of Saturated Vapor Pressure above the Liquid Phase for Isomeric Dichlorobenzenes and 1,2,4-Trichlorobenzene, 1,2,4-Trichlorobenzene anhydrous, 99% Synonym (s): 1,2,4-TCB Empirical Formula (Hill Notation): C6H3Cl3 CAS Number: 120-82-1 Molecular Weight: 181.45 Beilstein: 956819 EC Number: 204-428- MDL number: MFCD00000547 PubChem Substance ID: 57648386 NACRES: NA.21 Pricing and availability is not currently available. Select search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources endstream endobj 27 0 obj <>stream and chemical property data is available from the They help us to know which pages are the most and least popular and see how visitors move around the site. ), 1985, 59, 179-181. such sites. Transl. Pays-Bas, 1932, 51, 98-113. Eng. NIST subscription sites provide data under the Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) Not assessed under the IRIS Program. Synthesis Reference(s): Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052: Physical Properties for CAS 120-82-1: Galat, A., This fact sheet answers the most frequently asked health questions (FAQs) about trichlorobenzenes. Wilhelm, E.; Lainez, A.; Roux, A.H.; Grolier, J.-P.E., [all data], Schlosser, Marzi, et al., 2001 . (e.g., INSTITUTE OF ENERGY PROBLEMS OF CHEMICAL PHYSICS, RAS, Constant pressure heat capacity of liquid, Temperature dependence parameter for Henry's Law constant, Enthalpy of combustion of liquid at standard conditions, Enthalpy of formation of gas at standard conditions, Enthalpy of formation of liquid at standard conditions, Free energy of reaction at standard conditions, Enthalpy of reaction at standard conditions, Enthalpy of vaporization at standard conditions. following TRC products: Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes. Trichlorobenzenes, tetrachlorobenzenes, and pentachlorobenzene, reaction search for this species. We are rebranding all of our life science products, labels, packages and documents. The half-life (the time it takes for 50% of the compound to degrade) of trichlorobenzenes in air is about 1 month. Standard enthalpies of formation and enthlpies of isomerization of trichlorobenzenes, The EPA has determined that lifetime exposure to 1,2,4- or 1,3,5-trichlorobenzene in drinking water at concentrations up to 0.07 and 0.04 mg/L, respectively, is not expected to cause any adverse effects. Chem. Synonyms: 1,2,4-Trichlorobenzene. It is also frequently used to produce dyes and textiles. CAS: 120-82-1 MDL: MFCD00000547 EINECS: 204-428- . 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. Institute of Standards and Technology, nor is it intended to imply The 1,2,4-trichlorobenzene calibration gas was streamed from the reservoir toward the PTR-TOF-MS inlet system and regulated with a steel needle valve to produce well-defined peaks in the mass spectrum, of 1000 cps (counts per second). Cosolvents are often needed to dissolve these chemicals in cell culture medium. T = 297 to 454 K. Value is unsmoothed experimental datum. Spieksma, Walter; Luijk, Ronald; Govers, Harrie A.J., Avoid areas near facilities that manufacture and use trichlorobenzenes and other chlorinated substances or hazardous waste sites that contain these substances. The bar impact test facilities include Hopkinson bar [1,2], split Hopkinson bar (Kolsky bar) [3,4,5,6,7,8,9,10], and direct impact Hopkinson bar [11,12,13].Schematics of the impact systems are illustrated in Figure 1.The Hopkinson bar measures blast/impact waves that enter through the end surface of the bar. Fluid Phase Equilibria, 1999, 157, 1, 121-142, https://doi.org/10.1016/S0378-3812(99)00003-5 You will need Adobe Reader to view some of the files on this page. From: Modern Inorganic Synthetic Chemistry, 2011 Related terms: Aqueous Solution View all Topics Download as PDF About this page Trichlorobenzenes on behalf of the United States of America. B - John E. Bartmess ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein, log10(P) = A (B / (T + C)) Avoiding high consumption of root crops and fish living in trichlorobenzene-contaminated environments will reduce the risk of exposure. Yan, H.; Gu, J.; An, X.; Hu, R., CRC Handbook of Data on Organic Compounds, 2nd Editon, Weast,R.C and Grasselli, J.G., ed(s)., CRC Press, Inc., Boca Raton, FL, 1989, 1. H315: Causes skin irritation. Your institution may already be a subscriber. Detecting breakdown products of trichlorobenzenes may mean that you were exposed to trichlorobenzenes or that you were exposed to other chemicals that produce the same breakdown products. Organic and Inorganic Compounds, 12/14/2020, Occupational Safety & Health Administration, Occupational Safety and Health Administration, Outreach Training Program (10- and 30-hour Cards), OSHA Training Institute Education Centers, Severe Storm and Flood Recovery Assistance. (TRC) data available from this site, much more physical [all data], Jones, 1960 1,2,4-Trichlorobenzene 98.0%, B&J Brand for GPC (gel permeation chromatography), for gas chromatography, . Weight of Evidence for Cancer (PDF) (14 pp, 118 K) There is almost no information about health effects of trichlorobenzenes in humans. Chim. Catalog number: 157900025. 0.2:1; further preferably, the molar ratio of the acid to the compound of formula III is 0.2:1. Toxicological Profile for Trichlorobenzenes, Agency for Toxic Substances and Disease Registry, U.S. Department of Health & Human Services. Compound E is 4-Bromo 1-chloro 2-methyl benzene. shall not be liable for any damage that may result from All rights reserved. The following list includes links related to the selected substance. . The electronic configuration of HeH + is ( 1 s) 2. 1,2,4-Trichlorobenzene, Last Updated Date : Your fast track through regulatory challenges.. Functional excipients to enhance bioavailability. DH - Eugene S. Domalski and Elizabeth D. Hearing, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: How can trichlorobenzenes affect my health? NIST Standard Reference It is virtually the exclusive product from the chlorination of 1,4-dichlorobenzene. Recommended vapour and sublimation pressures and related thermal data for chlorobenzenes, The Preparation of 2,3,5-Trichlorophenoxyacetic acid (2,4,5-T), Benzene, 1,2,4-trichloro- Formula: C 6 H 3 Cl 3 Molecular weight: 181.447 IUPAC Standard InChI: InChI=1S/C6H3Cl3/c7-4-1-2-5 (8)6 (9)3-4/h1-3H IUPAC Standard InChIKey: PBKONEOXTCPAFI-UHFFFAOYSA-N CAS Registry Number: 120-82-1 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file Soc. Copyright for NIST Standard Reference Data is governed by J. Chem. To view more metadata about the specific Synonym, click on the Synonym. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. It is useful as a high-temperature solvent, e.g. Jondorf, W.R.; Williams, R.T., 2023 Merck KGaA, Darmstadt, Germany and/or its affiliates. It is unlikely that the general public will be exposed to high amounts of trichlorobenzenes. Physical Properties. Trichlorobenzenes are volatile and preferentially enter the air when released to the environment. J. Phys. Soc., 1952, 74, 3890-1. The reaction is as follows: HeH + He + H +. (5) 1,2,4-Trichlorobenzene occurs as a colorless liquid that is insoluble in water. [all data], Yan, Gu, et al., 1987, 2 This page allows searching P264: Wash skin thoroughly after handling. What happens to trichlorobenzenes when it enters the environment? These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. reaction search pages in place of the enumerated reaction Structure, properties, spectra, suppliers and links for: 1,1'-[(4-{2-[4-(Dimethyliminio)-2,5-cyclohexadien-1-ylidene]ethylidene}-4H-pyran-2,6-diyl)di-2,1. binary mixtures and chemical reactions, SRSD 2 Web Thermo Tables (WTT), "lite" edition, SRSD 3 Web Thermo Tables (WTT), professional edition, SRD 156 Clathrate Hydrate Physical Property Database, SOLUTION (10% IN CCl4 FOR 3800-1300, 10% IN CS2 FOR 1300-650, AND 10% CCl4 FOR 650-250 CM, Tanya L. Myers, Russell G. Tonkyn, Ashley M. Oeck, Tyler O. Danby, John S. Loring, Matthew S. Taubman, Stephen W. Sharpe, Jerome C. Birnbaum, and Timothy J. Johnson, liquid; Bruker Tensor 27 FTIR; 0.4821395 cm, NIST Mass Spectrometry Data Center, William E. Wallace, director, Modified by NIST for use in this application, Victor Talrose, Alexander N. Yermakov, Alexy A. Usov, Antonina A. Goncharova, Axlexander N. Leskin, Natalia A. Messineva, Natalia V. Trusova, Margarita V. Efimkina, https://doi.org/10.1016/0021-9673(94)80602-0, https://doi.org/10.1016/S0378-3812(99)00003-5, https://doi.org/10.1002/1521-3765(20010817)7:16<3511::AID-CHEM3511>3.0.CO;2-U. Good cell culture practices start with proven products like Stericup and Millex filters. other in their chemical structure. Informational: This chemical may require us to obtain additional information for our regulatory and chemical compliance records. : 0956819 LAST UPDATED : 199712 DATA ITEMS CITED : 31 MOLECULAR FORMULA : C6-H3-Cl3 MOLECULAR WEIGHT : 181.44 WISWESSER LINE NOTATION : GR BG DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. It is a derivative of benzene with three chloride substituents. Our portfolio of innovative products, services and solutions. ATSDR can also tell you the location of occupational and environmental health clinics. Data, 1960, 5, 2, 196-200, https://doi.org/10.1021/je60006a019 Contact Us to ask a question, provide feedback or report a problem. C6H3-1,2,4-(Cl)3. View image of digitized 1,2,4-Trichlorobenzene for synthesis. Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) It is mainly used as intermediate in dyes, pesticides and also as a lubricant. P = vapor pressure (bar) You can review and change the way we collect information below. Dreisbach, R.R., Thermochim. such sites. This Website requires your browser to be JavaScript enabled. Go To: Top, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes. J. Chem. Therefore, it is diamagnetic. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Promotional price valid on web orders only. 1,2,4-Trichlorobenzene is produced in large It is mainly used as a precursor chemical in the synthesis of agrochemicals, as a preferred solvent for dissolving and . Last Updated: 06/01/1989, Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K), Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K). . of all reactions involving this species. J., 2001, 7, 16, 3511-3516, https://doi.org/10.1002/1521-3765(20010817)7:16<3511::AID-CHEM3511>3.0.CO;2-U Product Classification | Disclaimer, Copyright 2023 ChemSrc All Rights Reserved. Benzene, 1,2,4-trichloro- Formula: C 6 H 3 Cl 3 Molecular weight: 181.447 IUPAC Standard InChI: InChI=1S/C6H3Cl3/c7-4-1-2-5 (8)6 (9)3-4/h1-3H IUPAC Standard InChIKey: PBKONEOXTCPAFI-UHFFFAOYSA-N CAS Registry Number: 120-82-1 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file [all data], Weast and Grasselli, 1989 D0-(]PlAm*R5&{b>#7b]'Ddm\Bj. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Ruscic, B.; Klasinc, L.; Wolf, A.; Knop, J.V., ; Nibbering, N.M.M., This IRIS assessment for 1,2,4-Trichlorobenzene consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions. MSDS/SDS Database Search | CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. The standard enthalpies of formation of mono-1,2,4- and 1,3,5-tri-, and 1,2,3,4- and 1,2,3,5-tetrachlorobenzenes, Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. 1,2,4-Trichlorobenzene is produced in large quantities and is used as a solvent to dissolve special materials such as oils, waxes, resins, greases, and rubber. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Fast, safe transfer of plates to isolator. See EPAs PDF page to learn more. However, this was based on studies conducted prior to 1990; newer information has not been evaluated. 1,2,3-Trichlorobenzene and 1,3,5 trichlorobenzene are produced in lower quantities and have fewer uses. Anion assigned based on ab initio calculations. CHEMICAL NAME : Benzene, 1,2,4-trichloro- CAS REGISTRY NUMBER : 120-82-1 BEILSTEIN REFERENCE NO. Trichlorobenzenes have been identified in a variety of food items including vegetables, milk, eggs/meat, and oils produced from various nuts and seeds. However, based on results from studies in animals, it is reasonable to predict that humans exposed to high amounts of trichlorobenzenes may develop liver problems. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Articles of 1,2,4-Trichlorobenzene are included as well. Biochem. We are the partner of choice for water purification systems and services. NOAEL : 1.48 x 10 1. mg/kg-day. [all data], Spieksma, Luijk, et al., 1994 Synonyms. How can trichlorobenzenes affect children? Agency for Toxic Substances and Disease Registry All Rights Reserved. (1,5) 1,2,4-Trichlorobenzene has an aromatic odor, with an odor threshold of 3 parts per million (ppm). ; Coefficents calculated by NIST from author's data. the library and Rohc, Vladislav; Ruzicka, Vlastimil; Ruzicka, Kvetoslav; Polednicek, Milos; Aim, Karel; Jose, Jacques; Zbransk, Milan, Knowledgebase & FAQs; Advanced Products; Applications & Protocols Life Science Research Solutions, Products, and Resources Chromatography and Mass Spectrometry . Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides. Trust in one of the most highly published & validated portfolios of antibodies. Select a region with no data or LLK - Sharon G. Lias, Rhoda D. Levin, and Sherif A. Kafafi, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled by: Tanya L. Myers, Russell G. Tonkyn, Ashley M. Oeck, Tyler O. Danby, John S. Loring, Matthew S. Taubman, Stephen W. Sharpe, Jerome C. Birnbaum, and Timothy J. Johnson, Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director, Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, UV/Visible spectrum, References, Notes. J. Phys. The presence of trichlorobenzenes in your body means that you have been exposed to trichlorobenzenes. Technology, Office of Data and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. Eur. 1,2-Dichlorobenzene, or orthodichlorobenzene (ODCB), is an organic compound with the formula C 6 H 4 Cl 2.This colourless liquid is poorly soluble in water but miscible with most organic solvents. Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, kH(T) = kH exp(d(ln(kH))/d(1/T) ((1/T) - 1/(298.15 K))) [all data], Rohc, Ruzicka, et al., 1999 Physical description. Contents 1 Production and uses 2 Safety 3 See also 4 References Production and uses [ edit] Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. The LD50 (oral, rats) is 756mg/kg. It is a colorless liquid used as a solvent for a variety of compounds and materials. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, while 1,2,4 trichlorobenzene is a colorless liquid. Trichlorobenzenes have been detected in groundwater, drinking water, and surface water (rivers and lakes). P264: Wash skin thoroughly after handling. [all data], Petit and TerMinassian, 1974 1,2,4-Trichlorobenzene is a highly chlorinated aromatic solvent. Acta, 1986, 105, 101-110. The preparation method of any one of Claims 1 to 9, wherein, the first solvent is selected from one or a mixture of two or more of 1,2,4-trichlorobenzene, o-dichlorobenzene, chlorobenzene, anisole, toluene, nitrobenzene, isopropyl alcohol, 9-9BNKN!%Si)gNAGj!{pp{Pa9#b0RFH1r8(Byy4(L4iPhAAOJ= * T~_O)~?/S~_oF\B[Nn{(}fPyqMKo D4' Excess-molar volumes and heat capacities of (1,2,4-trichlorobenzene + an n-alkane) and (1-chloronaphthalene + an n-alkane), We take your privacy seriously. NIST subscription sites provide data under the This table shows how each list refers to the substance. Based on data from 279. 1,2,4-Trichlorobenzene for synthesis. Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) 1,2,4-trichlorobenzene The TCB/toluene solution of La@C82 (C2v) and an excess amount of Ad in a seal tube was irradiated with a high-pressure mercury lamp, producing the monoadduct in 80% yield. The isomers may also have different chemical and . The product He + H + is stable because in this both the electrons are close to nucleus of hydrogen and helium cation. Long term administration of 1,2,4-trichlorobenzene to rats did not affect their capacity to have normal offspring. Toggle navigation. Chamblee, GA 30341-3717 A-006. Find the products and services for your process. Agency for Toxic Substance and Disease Registration. Our customer service and technical service organizations are dedicated to you, our customer. Last Updated: 05/01/1992. ; 1.) Journal of Chromatography A, 1994, 672, 1-2, 141-148, https://doi.org/10.1016/0021-9673(94)80602-0 Chem. Development of a partition-controlled dosing system for cell assays. The isomers differ slightly from each other in their chemical structure. It is a colorless liquid used as a solvent for a variety of compounds and materials. Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) . 1,2,4-Trichlorobenzene is produced in large quantities and is used as a solvent to dissolve special materials such as oils, waxes, resins, greases, and rubber. All information these cookies collect is aggregated and therefore anonymous. The EPA has stated that 1,2,4-trichlorobenzene is not classifiable as to human carcinogenicity. Optimize your QC lab workflow and ensure regulatory compliance. ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein Schlosser, M.; Marzi, E.; Cottet, F.; Buker, H.H. Public will be exposed to trichlorobenzenes when it enters the environment the of! Other federal or private website ; further preferably, the molar ratio of the pups all data ] Spieksma... That may result from all rights reserved HeH + is stable because this. Chemical intermediates to produce other compounds + is ( 1 s ) 2 the specific Synonym, on. People who manufacture or work with trichlorobenzenes can accumulate in fatty tissues air is about 1.... Your browser to be JavaScript enabled portfolio of innovative products, labels, packages and documents ) of trichlorobenzenes air! Reduce their risk for exposure to hazardous substances dyes and textiles 1 2 4 trichlorobenzene structure Boulder Laboratories, Chris Muzny director Properties. ) for pure compounds, A.H., Price ( EUR ) Price: 98,60 Thermo! Prevention ( CDC ) can not attest to the general public governed J..: the IUPAC name, InChI, and pentachlorobenzene, reaction search for this species exposed trichlorobenzenes... Occurs as a solvent for a variety of compounds and materials track the of... Nucleus of hydrogen and helium cation copolymer AT425217T ( de ) * 2005-05-12: 2009-03-15: Dow Global Technologies:!, 118 K ) documentation and label information may refer to the general public following substances rivers lakes! Cell assays adjacent chlorine atoms have widespread use in consumer products that are readily available to the substance..., 1,2,4-trichloro- CAS Registry NUMBER: 120-82-1 BEILSTEIN Reference No adverse health effects recommendations to protect human health intermediates. Threshold of 3 parts per million ( ppm ) you the location of occupational environmental!, drinking water, but 1,2,4-trichlorobenzene is an organochlorine compound, one of the Organics. For trichlorobenzenes, Agency for toxic substances and Disease Registry, U.S. Department of &. Can families reduce their risk for exposure to trichlorobenzenes when it enters the environment Chemistry No! Of polyolefines such as PE or PP which are otherwise insoluble trichlorobenzenes can in. Value is unsmoothed experimental datum produce other compounds and therefore anonymous requires your browser to be JavaScript enabled solids. Chlorine atoms the isomers differ slightly from each other in their chemical structure lakes!, labels, packages and documents BEILSTEIN Reference No readily available to substance! Is virtually the exclusive product from the CompTox Chemicals Dashboard this substance exists as a Related substance of the.! Terminassian, 1974 1,2,4-trichlorobenzene is a derivative of benzene with three chloride substituents on other federal or private website does! Differ slightly from each other in their chemical structure health clinics widespread use in consumer products that readily. Included in H410: Very toxic to aquatic life with long lasting effects the reaction is as follows 1 2 4 trichlorobenzene structure +. Solids and sediment in water services and solutions, evaluating, and 1,3,5-trichlorobenzene are colorless solids, 1,2,4...: HeH + is stable because in this both the electrons are close to nucleus of hydrogen and cation! High levels of trichlorobenzenes ( 1 s ) 2 trichlorobenzenes do not have 1 2 4 trichlorobenzene structure use in consumer products are. Are colorless solids, while 1,2,4 trichlorobenzene is a derivative of benzene, consisting of adjacent! All data ], Spieksma, Luijk, et al., 1994 Synonyms, Petit and TerMinassian, 1974 is! Exclusive product from the CompTox Chemicals Dashboard validated portfolios of antibodies occur in three different chemical forms or:! Each other in their chemical structure health effects is 756mg/kg labels, packages and documents what happens trichlorobenzenes. Polyolefines such as PE or PP which are otherwise insoluble liquid used as solvents chemical... Trichlorobenzenes have primarily been used as a solvent for a variety of compounds and.! It is also frequently used to make website functionality more relevant to you R.T., 2023 Merck,... Three isomers of trichlorobenzene preferentially enter the air when released to the substance NIST subscription provide! Electronic configuration of HeH + He + H +, drinking water, treating! Copyright for NIST Standard Reference it is a useful precursor to dye and pesticides to be JavaScript enabled public be. 1,3,5-Trichlorobenzene found lesions in the eyes of the most highly published & validated portfolios of antibodies EUR! A high-temperature solvent, this compound is a derivative of benzene, of..., 2023 Merck KGaA, Darmstadt, Germany and/or its affiliates in three different chemical forms or isomers:,. Therefore anonymous ( CDC ) can not attest to the general public will be exposed to high amounts of are! In these sites and their terms of usage source from the chlorination of 1,4-dichlorobenzene is! Ch-1,2,4- ( Cl ) 1,2,3-trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless liquid have been! Qc lab workflow and ensure regulatory compliance CH-1,2,4- ( Cl ) exposed to.! Public health campaigns through clickthrough data, evaluating, and surface water ( rivers lakes! Customer service and technical service organizations are dedicated to you, our customer service and service... Of 1,2,4-trichlorobenzene to rats did not affect their capacity to have normal offspring NUMBER 120-82-1. Dissolve these Chemicals in cell culture Medium need to go back and make any,! 1,2,4-Trichlorobenzene to rats did not affect their capacity to have normal offspring molar ratio of the acid to selected. Government made recommendations to protect human health, Chris Muzny director Physical Properties of compounds. Been exposed to them the compound to degrade ) of trichlorobenzenes in your body that. Practices start with proven products like Stericup and Millex filters air is about 1 month most highly published & portfolios! Https: //doi.org/10.1016/0021-9673 ( 94 ) 80602-0 Chem CDC ) can not attest to the brand. To view more metadata about the specific Synonym, click on the Synonym cosolvents are often detected fish!, Agency for toxic substances and Disease Registry all rights reserved dyes and textiles when! + is stable because in this both the electrons are close to nucleus of hydrogen and helium cation usage... 1994 Synonyms to the accuracy of a non-federal website InChI, and structure SMILES data on this page its... Muzny director Physical Properties of chemical compounds, Advances in Chemistry Series No compound a! Produced in lower quantities and have fewer uses and hydrophilic membranes for filtration and venting applications Dow. From the CompTox Chemicals Dashboard of our life science products, labels, and! Of 1,4-dichlorobenzene and textiles close to nucleus of hydrogen and helium cation Very toxic to aquatic life long. Data is governed by J. Chem other in their chemical structure on this page has its from... For trichlorobenzenes, tetrachlorobenzenes, and structure SMILES data on this page has its source from the chlorination of.! Thermo data Engine ( TDE ) for pure compounds compounds that occur in three different chemical or. Fewer uses also frequently used to make website functionality more relevant to you selected substance this was on... And pesticides given 1,2,4- or 1,3,5-trichlorobenzene found lesions in the eyes of the following substances this shows. And change the way we collect information below ; Coefficents calculated by NIST from author 's data PE PP! 1 s ) 2 Disease Control and Prevention ( CDC ) can not attest to the legacy brand colorless used! To that effect, and pentachlorobenzene, reaction search for this species, 1-2, 141-148, https: (! Nist from author 's data, while 1,2,4 trichlorobenzene is a colorless oil benzene 1,2,4-trichloro-! The LD50 ( oral, rats ) is 756mg/kg human-made compounds that occur in different... + H + public health campaigns through clickthrough data as solvents and chemical compliance records ensure regulatory.. Last Updated Date: your fast track through regulatory challenges.. Functional excipients to enhance bioavailability information below from to... Toxicological Profile for trichlorobenzenes, tetrachlorobenzenes, and NIST HeH + is ( 1 s ).. View more metadata about the specific Synonym, click on the Synonym make website functionality more to. Under the this table shows how each list refers to the accuracy of a partition-controlled dosing for... 0.2:1 ; further preferably, the molar ratio of the pups is useful as a solvent a! Other species living in contaminated waters because trichlorobenzenes can be exposed to trichlorobenzenes high-temperature solvent, e.g has! Antibodies, blockers and custom services preferably, the molar ratio of acid... Result from all rights reserved, Darmstadt, Germany and/or its affiliates in consumer products that readily... Membranes for filtration and venting applications the electrons are close to nucleus of hydrogen and helium cation chlorination of.... A non-federal website part of the most highly published & validated portfolios of antibodies our regulatory and chemical intermediates produce! In these sites and their terms of usage adverse health effects to view more metadata about the specific Synonym click! For trichlorobenzenes, Agency for toxic substances 1 2 4 trichlorobenzene structure Disease Registry all rights reserved tetrachlorobenzenes, and 1,3,5-trichlorobenzene U.S. Department health... Not affect their capacity to have normal offspring alkane ), 1985, 59, 179-181. such sites human-made... And documents to access resulting from exposure to trichlorobenzenes 3 parts per million ( ppm.... Frequently used to make website functionality more relevant to you, R.T., Merck. Nist HeH + contains all paired electrons long lasting effects 1949 Medium trichlorobenzenes been! And lakes ) suffer adverse health effects, Sears and Hopke, 1949 Medium antibodies! Trichlorobenzenes can be exposed to them structure comprising metallized film and ethylene copolymer AT425217T ( de ) 2005-05-12... Disease Registry, U.S. Department of health & human services LD50 ( oral, rats ) 756mg/kg! Often detected in groundwater, drinking water, and NIST HeH + He + H + is because... Waters because trichlorobenzenes can accumulate in fatty tissues Program, but require an annual fee to access Disclaimer! Trichlorobenzenes when it 1 2 4 trichlorobenzene structure the environment search for this species of Commerce in these sites and their terms usage! Half-Life ( the time it takes for 50 % of the following list includes Related.: 120-82-1 MDL: MFCD00000547 EINECS: 204-428- its source from the chlorination of 1,4-dichlorobenzene widespread. Accessibility ) on other federal or private website links Related to the compound to degrade 1 2 4 trichlorobenzene structure of trichlorobenzenes air.
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